Priscilla is derived from Latin roots, meaning 'ancient' or 'old'. It was popular among early Christians as they associated it with Priscilla and Aquila, a couple mentioned in the New Testament who aided Paul the Apostle on his missionary journeys. In some languages like Italian and Spanish, it is often shortened to the nickname Prisca.
"Prisilla experienced peak popularity between 1979 and 1999 with over 20 births per year. However, it has since declined, with fewer than 10 births annually since 2000."