Luisana is of Spanish origin, derived from the male name Luis, which means 'famous warrior'. The female version was popularized by the Argentine singer and actress, Luján Luisana Lopilato, often simply known as Luisana.
The name Luisana saw its peak popularity between 1982 and 1984 with 37, 131, and 33 births respectively. However, it has since become quite uncommon, with only a handful of births each year since the late 1990s. The total number of births registered as Luisana over this period is 586.