Santee is an uncommon given name of Native American origin, derived from the name of the Santee tribe, one of the Sioux nations. This name has been used occasionally in the United States and Canada, particularly among families with Native American heritage or those drawn to distinctive names.
The name Santee experienced fluctuations in popularity from 1965 to 2023, with a peak of 13 births in 1977 and a recent surge with six births each in 2020 and 2023. Over this period, there were a total of seventy-four babies named Santee.