Isa is of Hebrew origin, translating to 'he will laugh'. It is often considered a variant of the name Isaac. In some cultures, it is used independently as a given name for girls. Isa is also found in various other languages and cultures, including Spanish and Arabic. It has been employed by notable figures throughout history, such as Spanish poet Vicente Aleixandre, who went by the pseudonym Isa.
The name Isa appears to have gained popularity significantly over time, with a notable increase in usage from the late 1970s onwards. The highest number of births recorded for this name was in 2023, with 169 occurrences.