Dejuan is of African American origin, derived from Spanish components "de" meaning "of," and "Juan" meaning "God is gracious." It emerged as a variant spelling of the more common Dejon, which follows the same etymology. The name gained popularity in the United States during the mid-20th century, particularly among African American communities.
The name Dejuan saw a consistent rise in popularity between 1971 and 1984, with birth counts ranging from 5 to 8 annually.