Machias is of Greek origin, derived from the word 'makhes', meaning 'battle' or 'strife'. It is a rare unisex name, but it has been predominantly used for males. The name Machias was popularized in the 18th century by the French explorer Jean-Nicolas Délietroz, who named a bay on the coast of Alaska after his friend Jacques Machault. In some variations of spelling, such as Machiavelli or Machiavel, it has been associated with the Italian political philosopher Niccolò Machiavelli.
Machias is quite uncommon; only 5 babies were named Machias in 2006.