Isai is of Hebrew origin and means 'God is my salvation'. It is primarily used as a male given name, though it can also be used for females. The name Isai has been used throughout history, notably by Saint Isaias, a martyr in the 3rd century. In the Bible, Isaiah was one of the major prophets. The name has gained popularity worldwide and has numerous variations such as Isaiah, Isac, and Isak among others.
The name Isai has had a sporadic popularity over the years, with no consistent trend or increasing frequency of births from 1990 to 2012. The highest number of births recorded was six times each in 1992 and 2000, while other years saw either five or fewer births. Overall, there were a total of twenty-seven babies named Isai born during this period.