Irmagene is of American origin, derived from the Germanic elements 'Irma' and 'Gene', meaning 'universal peace'. It was popular among families of German descent who settled in the United States, particularly during the late 19th to early 20th centuries. Irmagene is often associated with strong, independent women who have left their mark on American history.
Irmagene experienced a dip in popularity with only five births recorded in 1931 compared to seven in 1929, but overall, there were twelve Irmagenes born between those two years.