Muffy is of American origin, derived from 'Murphy', an Irish surname that was originally used as a given name. It gained popularity in the United States during the mid-20th century and has since been used as both a feminine given name and a nickname for longer names like Margaret or Muriel. The name Muffy is often associated with a playful, lively persona due to its youthful sound.
"Muffy was quite popular in 1978 with six babies given that name."