Esthefany is of Spanish origin, derived from Esther and combined with the suffix '-fany'. It means 'myrtle', a small evergreen shrub known for its fragrant flowers and leaves. The name Esthefany gained popularity in Spain during the late 20th century and has since been used internationally. It is often spelled interchangeably with Estefanía, Estefany, or Stefania, but it remains distinct from Stephanie, which is of French origin meaning 'crown'.
The name Esthefany experienced fluctuations in popularity over the years with a peak of 14 births in 2001 and a low of 5 births in both 1997 and 2011, totaling 198 births from 1989 to 2017.