Marcellene is of Latin origin, derived from the Roman family name Marcellus. The name's meaning is often attributed to 'noble' or 'warrior', reflecting its historical roots in ancient Rome. It is a variant spelling of Marcellina, which was more commonly used during the Middle Ages. Today, Marcellene is considered somewhat rare, but it adds a unique touch to those who bear it.
The name Marcellene experienced varying popularity over the decades, with a peak of 13 births in 1929 and a consistent low of 5 births from 1934 to 1938 inclusive. After a gap of 17 years, there were again 6 births in 1946. The name remained relatively uncommon thereafter, with only two instances each in the late 1940s and early 1950s, and 1961.